Histidine and Hair Growth – Mechanism of Action

Histidine and Hair Growth – Mechanism of Action

Histidine, one of 18 amino acids playing an essential role in hair growth and maintenance, is an ingredient in Divi's Scalp Serum, Shampoo & Conditioner, which can promote hair growth by improving scalp health.


People lose anywhere from 50-100 strands of hair per day. This is natural. However, if you're noticing more hair loss than usual or experiencing hair thinning, you could be dealing with a nutritional deficiency, high stress or an imbalance of hormones.


Here, we explore how histidine is a powerful and highly beneficial ingredient in Divi’s products, designed to help restore the scalp and hair to a healthy condition.


Introduction to Histidine


Histidine, also called l-histidine, is a type of semi-essential amino acid most people get from food as the body cannot produce it. Histidine helps regulate the body's inflammatory processes, allergic reactions and immune defense.


Amino acids are often described as the "building blocks of proteins" because they are used to make proteins and enzymes in the body. Keratin is a family of proteins making up significant portions of our hair and the topmost layer of our skin and nails, and histidine is one of 18 amino acids that make up keratin.


Histidine is also one of nine essential amino acids needed for hair, hormone regulation, new muscle growth, and the production of the red blood cells carrying nutrients and oxygen throughout the body, including to the epidermis and hair follicles.


The blood cells that histidine carries to the hair follicle stem cells nourish the hair bulb and deliver hormones, which modify hair growth and structure at different stages of life.


Histidine in Divi’s Scalp Care Products – How Does Histidine Help With Hair Growth?


You can find histidine in Divi's Scalp Serum, Shampoo & Conditioner. Our formulas are all-natural, lightweight, fast-absorbing and residue-free.


While Divi can't promise to solve the cause of your hair condition, it can slow down and prevent hair loss symptoms. Here are how Divi's products can help with hair growth thanks to the inclusion of histidine.


Soothes Dry Scalp


Histidine, along with other amino acids and ingredients found in Divi's Shampoo & Conditioner, can help soothe dry scalp and psoriasis with antioxidant properties.


The itchiness of a dry scalp can lead to scratching, injuring your hair follicles and hair loss. Histidine plays a role in helping human skin maintain hydration by improving its natural moisturizing factors and ability to withstand environmental damage.


Stops Shedding


Liquid amino acids can stop excessive hair shedding and breakage. By using hair masks and treatments that include amino acids, such as histidine, your hair may see a higher capability to retain moisture and improve hair regrowth.

Divi's Scalp Serum is a lightweight scalp serum infused with a powerful blend of amino acids, including histidine, to support thicker hair, aid scalp health, and prevent follicle damage.


Prevents Hair Damage and Softens Hair


Heat damage and too many chemicals (like hair gel, wax, spray or other hair care products) can affect the integrity of hair and the hair follicles. Liquid amino acids, such as histidine, can help restore the health and strength of your hair.


Histidine is proven to aid hair in strength and improving elasticity, specifically if your hair is low in porosity (your hair's ability to absorb and retain moisture) and there has been a weakening of hair follicles.


Conditions Helped by Histidine


While it is clear that amino acids in Divi's products play an essential role in hair growth and maintenance, this doesn't mean they should be relied upon to give you a full, flawless head of hair. Many factors are at play in the relationship between amino acids and hair growth, with some studies showing how those with a hair condition can benefit from histidine.


  • Androgenetic Alopecia – In a cross-sectional study of 100 people with hair loss, researchers observed a histidine deficiency in over 90% of participants with androgenic alopecia, commonly known as female- or male-pattern hair loss. Another study conducted in 1998 found evidence that oral l-cysteine (unknown dose) taken four times a day in combination with histidine, copper and zinc resulted in a significant increase in human hair growth (total hair count) after 50 weeks in 24 patients with androgenetic hair loss. It is also believed that histidine is co-transported with zinc, and zinc supplementation has been shown to improve hair regrowth and strength in patients with alopecia [4].
  • Telogen effluvium – In the same cross-sectional study mentioned above, researchers also observed a histidine deficiency in 77.78% of participants with telogen effluvium (TE).
  • Scalp psoriasis and scalp eczema – Histidine is a natural moisturizing factor (NMF) produced from the proteolysis of the histidine-rich protein filaggrin. It’s found in the upper epidermis and hair follicle. Trauma to the scalp can also trigger hair loss, often caused by scratching or picking scaly patches. It has been shown that once scalp psoriasis is soothed, most people with hair loss experience complete hair restoration and regrowth.
  • Atopic dermatitis – Evidence suggests histidine supplementation can enhance filaggrin processing and have beneficial effects in subjects with atopic dermatitis.
  • Thinning hair – It has been shown that histidine absorbs excess copper from the hair, and removing this excess copper shields hair more effectively from Ultraviolet A (UVA) and Ultraviolet B (UVB). This can cause hair to become brittle and break off prematurely.

Possible Side Effects of Histidine

Amino acids, such as histidine, are mostly considered safe in topical applications like with shampoos and scalp serums. In Divi's products, every ingredient is carefully measured, dermatologically tested, and contains the right balance of compounds.


Since hair loss can occur for several reasons, it's essential to talk with your doctor and identify what condition you have and its causes before pursuing hair loss treatments and any amino acid supplements.


Final Thoughts

You can use hair products like Divi's Scalp Serum, Shampoo & Conditioner that contain crucial amino acids to enhance scalp health and promote hair growth. Histidine, one of these amino acids, can support the hair growth cycle.

For a formula that gives you all the best amino acids for a healthier head of hair, check out Divi's Shampoo & Conditioner bundle to help you achieve positive results.